58 research outputs found
Recommendations and illustrations for the evaluation of photonic random number generators
The never-ending quest to improve the security of digital information
combined with recent improvements in hardware technology has caused the field
of random number generation to undergo a fundamental shift from relying solely
on pseudo-random algorithms to employing optical entropy sources. Despite these
significant advances on the hardware side, commonly used statistical measures
and evaluation practices remain ill-suited to understand or quantify the
optical entropy that underlies physical random number generation. We review the
state of the art in the evaluation of optical random number generation and
recommend a new paradigm: quantifying entropy generation and understanding the
physical limits of the optical sources of randomness. In order to do this, we
advocate for the separation of the physical entropy source from deterministic
post-processing in the evaluation of random number generators and for the
explicit consideration of the impact of the measurement and digitization
process on the rate of entropy production. We present the Cohen-Procaccia
estimate of the entropy rate as one way to do this. In order
to provide an illustration of our recommendations, we apply the Cohen-Procaccia
estimate as well as the entropy estimates from the new NIST draft standards for
physical random number generators to evaluate and compare three common optical
entropy sources: single photon time-of-arrival detection, chaotic lasers, and
amplified spontaneous emission
Quantum Key Distribution: Boon or Bust
Quantum Key Distribution (QKD) is an emerging cybersecurity technology which provides the means for two geographically separated parties to grow “unconditionally secure” symmetric cryptographic keying material. Unlike traditional key distribution techniques, the security of QKD rests on the laws of quantum mechanics and not computational complexity. This unique aspect of QKD is due to the fact that any unauthorized eavesdropping on the key distribution channel necessarily introduces detectable errors (Gisin, Ribordy, Tittel, & Zbinden, 2002). This attribute makes QKD desirable for high-security environments such as banking, government, and military applications. However, QKD is a nascent technology where implementation non-idealities can negatively impact system performance and security (Mailloux, Grimaila, Hodson, Baumgartner, & McLaughlin, 2015). While the QKD community is making progress towards the viability of QKD solutions, it is clear that more work is required to quantify the impact of such non-idealities in real-world QKD systems (Scarani & Kurtsiefer, 2009)
Optimizing Decoy State Enabled Quantum Key Distribution Systems to Maximize Quantum Throughput and Detect Photon Number Splitting Attacks with High Confidence
Quantum Key Distribution (QKD) is an innovative quantum communications
protocol which exploits the laws of quantum mechanics to generate
unconditionally secure cryptographic keying material between two geographically
separated parties. The unique nature of QKD shows promise for high-security
applications such as those found in banking, government, and military
environments. However, QKD systems contain implementation non-idealities which
can negatively impact their performance and security.In particular, QKD systems
often employ the decoy state protocol to improve system throughput and mitigate
the threat of Photon Number Splitting (PNS) attacks. In this work, a detailed
analysis of the decoy state protocol is conducted which optimizes both
performance in terms of quantum throughput and security with respect to
detecting PNS attacks. The results of this study uniquely demonstrate that the
decoy state protocol can ensure PNS attacks are detected with high confidence,
while maximizing the secure key generation rate at no additional cost.
Additionally, implementation security guidance is provided for QKD system
developers and users
Modeling, Simulation, and Performance Analysis of Decoy State Enabled Quantum Key Distribution Systems
Quantum Key Distribution (QKD) systems exploit the laws of quantum mechanics to generate secure keying material for cryptographic purposes. To date, several commercially viable decoy state enabled QKD systems have been successfully demonstrated and show promise for high-security applications such as banking, government, and military environments. In this work, a detailed performance analysis of decoy state enabled QKD systems is conducted through model and simulation of several common decoy state configurations. The results of this study uniquely demonstrate that the decoy state protocol can ensure Photon Number Splitting (PNS) attacks are detected with high confidence, while maximizing the system’s quantum throughput at no additional cost. Additionally, implementation security guidance is provided for QKD system developers and users
Razvoj i vrednovanje plutajućih tableta norfloksacina s produljenim zadržavanjem u želucu
Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxy propyl methylcellulose (HPMCK4M, HPMCK100M) and xanthan gum. Tablets were evaluated for their physical characteristics viz., hardness, thickness, friability, and mass variation, drug content and floating properties. Further, tablets were studied for in vitro drug release characteristics for 9 hours. The tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non-Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and the polymer rearrangement played an essential role in drug release. The best formulation (F4) was selected based on in vitro characteristics and was used in vivo radiographic studies by incorporating BaSO4. These studies revealed that the tablets remained in the stomach for 180 ± 30 min in fasting human volunteers and indicated that gastric retention time was increased by the floating principle, which was considered desirable for absorption window drugs.Razvijene su plutajuće tablete norfloksacina koje se produljeno zadržavaju u želucu i time povećavaju bioraspoloživost. Tablete su pripravljene metodom vlažne granulacije, koristeći hidroksipropil metilcelulozu (HPMCK4M, HPMCK100M) i ksantan gumu. Tabletama su određena fizikalna svojstva (čvrstoća, debljina, lomljivost i varijacija mase) te sadržaj ljekovite tvari i plutajuća svojstva. Nadalje, praćeno je oslobađanje ljekovite tvari in vitro tijekom 9 h. Uočeno je da je oslobađanje kontrolirano i produljeno te da tablete plutaju u ispitivanom mediju. Mehanizam oslobađanja nije slijedio Fickov zakon, što ukazuje da difuzija vode i promjene u strukturi polimera imaju bitnu ulogu u oslobađanju ljekovite tvari. Najbolja formulacija (F4) in vitro uporabljena je s dodatkom barijevog sulfata za radiografska ispitivanja in vivo. Ispitivanja na volonterima koji su apstinirali od hrane pokazala su da primjena plutajućih tableta produljuje vrijeme zadržavanja u želucu na 180 ± 30 min
Surface electrons at plasma walls
In this chapter we introduce a microscopic modelling of the surplus electrons
on the plasma wall which complements the classical description of the plasma
sheath. First we introduce a model for the electron surface layer to study the
quasistationary electron distribution and the potential at an unbiased plasma
wall. Then we calculate sticking coefficients and desorption times for electron
trapping in the image states. Finally we study how surplus electrons affect
light scattering and how charge signatures offer the possibility of a novel
charge measurement for dust grains.Comment: To appear in Complex Plasmas: Scientific Challenges and Technological
Opportunities, Editors: M. Bonitz, K. Becker, J. Lopez and H. Thomse
Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study
Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
This work was supported by a restricted research grant of Bayer AG
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